VEGF Antibody (C-1) is a high-quality monoclonal VEGF antibody (also referred to as a VEGFA antibody) suitable for the detection of rat, mouse, and human VEGF protein. VEGF Antibody (C-1) is available as an unconjugated anti-VEGF antibody and several forms of conjugated anti-VEGF antibody including agarose, HRP, PE, FITC and some conjugates of Alexa Fluor.
The onset of angiogenesis is believed to be an early event of tumorigenesis and may facilitate tumor development and metastasis. Several growth factors with angiogenic activity have been described. You can also get a free secondary antibody online. These include fibroblast growth factor (FGF), platelet growth factor (PDGF), and vascular endothelial growth factor (VEGF).
VEGF is a dimeric glycoprotein with structural homology to PDGF. Several VEGF variants that arise from alternative mRNA splicing have been described. It is thought that VEGF may act as a factor in tumor angiogenesis in vivo because the expression pattern of VEGF is consistent with its role in embryonic angiogenesis. In staining application, VEGF antibody (C-1) showed cytoplasmic staining.
VEGF mRNA is produced in some primary tumors, VEGF is produced by tumor cell lines in vitro, and the mitogenic activity of VEGF appears to be limited to endothelial cells. A member of the PDGF receptor family, Flt, has been identified as a high-affinity receptor for VEGF.
VEGF has a variety of effects on the vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. Currently, the VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PLGF. VEGF and its receptor system have been shown to be key regulators in the cellular signaling of angiogenesis.