Medical storage units, such as cartons and bags, are expensive to produce and hard to maintain. FFPE is a solution that allows the medical community to store tissues and fluids without having the added expense of disposing of them.

Generally, tissue specimens are stored in formalin-fixed paraffin-embedded (FFPE) blocks. The FFPE block is composed of an embedding medium, a polyester resin with a chemical cross-linking agent, and polyethylene glycol that hardens and preserves the specimen. The tissue specimen is put in a specially designed vessel or petri dish, which is then placed in a fixative solution to preserve the ffpe block storage specimen as it would be outside the body.

FFPE in Modern Research

Image Source: Google

An FFPE block is a small free-floating fragment of DNA that is typically about 100,000 to 500,000 base pairs in length. It is an experimental method for storing biological material in a frost-free freezer where it does not coagulate or freeze. Researchers store RNA and DNA samples by cutting off the end of the molecule and leaving it floating in liquid nitrogen at -196 degrees Celsius. They then store it in suspension and run it through a simple centrifuge that separates out the fragments and puts them into individual vials that are sealed using liquid nitrogen.

With FFPE block storage, you can store as many files as needed and access them instantly. Plus, it is much more cost-effective than other methods of storage. FFPE block storage is a type of DNA sequencing technology that provides the best possible results. This method removes the need for costly, time-consuming gel electrophoresis and it allows users to store a large volume of DNA at one time. FFPE storage has many advantages and these are listed below: 

  • more efficient storage
  • does not require overhead backup power
  • less risk of data loss